Price range: $268.00 through $328.00
Background:
This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. Mutations in this gene have been associated with mental retardation autosomal recessive 47 (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015],
| Size | 50μL/100μL |
| Target | Formin 2 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 180kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FMN2. AA range:1541-1590 |
| Specificity | Formin 2 Polyclonal Antibody detects endogenous levels of Formin 2 protein. |
| Gene Name | FMN2 |
| Protein Name | Formin-2 |
| Other Name | FMN2; / Formin-2 |
| Species | Human |
| Gene ID | 56776 |
| Uniprot | Q9NZ56, |
| Species.1 | Mouse |
| Gene ID.1 | 54418 |
| Uniprot.1 | Q9JL04 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytoskeleton . Cytoplasm, cytosol . Cytoplasm, perinuclear region . Nucleus . Nucleus, nucleolus . Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasm, cell cortex . Colocalizes with the actin cytoskeleton (PubMed:20082305). Recruited to the membranes via its interaction with SPIRE1 (By similarity). Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Accumulates in the nucleus following DNA damage (PubMed:26287480). . |
| Tissue Expression | Expressed almost exclusively in the developing and mature central nervous system. |
| Signaling_pathway | |
| Research Areas | |
| Function | PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence Caution:Contaminating sequence. Sequence of unknown origin in the C-terminal part.,similarity:Belongs to the formin homology family. Cappuccino subfamily.,similarity:Contains 1 FH1 (formin homology 1) domain.,similarity:Contains 1 FH2 (formin homology 2) domain.,tissue specificity:Expressed almost exclusively in the developing and mature central nervous system., |
