Price range: $268.00 through $328.00
Background:
This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012],
| Size | 50μL/100μL |
| Target | FOXG1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 54kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FOXG1 AA range: 247-297 |
| Specificity | This antibody detects endogenous levels of FOXG1 at Human/Mouse/Rat |
| Gene Name | FOXG1 FKH2 FKHL1 FKHL2 FKHL3 FKHL4 FOXG1A FOXG1B FOXG1C |
| Protein Name | FOXG1 |
| Other Name | |
| Species | Human |
| Gene ID | 2290 |
| Uniprot | P55316, |
| Species.1 | Mouse |
| Gene ID.1 | 15228 |
| Uniprot.1 | Q60987, |
| Species.2 | Rat |
| Gene ID.2 | 24370 |
| Uniprot.2 | Q00939 |
| Cellular Localization | Nucleus . |
| Tissue Expression | Expression is restricted to the neurons of the developing telencephalon. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> FoxO signaling pathway |
| Research Areas | >>FoxO signaling pathway |
| Function | Caution:PubMed:7959731 claims that there are 3 different FOXG1 proteins, FOXG1A, FOXG1B, and FOXG1C. It was latter found that there is only one gene and the differences between these three may be sequencing errors since the protein is coded in a unique exon.,Function:Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Interacts with KDM5B.,tissue specificity:Expression is restricted to the neurons of the developing telencephalon., |
