Price range: $288.00 through $368.00
Background:
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],
| Size | 50μL/100μL |
| Target | FOXM1 Phospho Ser35 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 83kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | phosphate |
| Recommended Dilution Ratio | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized phosho peptide around human FoxM1 (Ser35) |
| Specificity | This antibody detects endogenous levels of Human FoxM1 (phospho-Ser35) |
| Gene Name | FOXM1 FKHL16 HFH11 MPP2 WIN |
| Protein Name | Forkhead box protein M1 (Ser35) |
| Other Name | Forkhead box protein M1; / Forkhead-related protein FKHL16; / Hepatocyte nuclear factor 3 forkhead homolog 11; / HFH-11; / HNF-3/fork-head homolog 11; / M-phase phosphoprotein 2; / MPM-2 reactive phosphoprotein 2; / Transcription factor Trident; / Winged-helix factor from INS-1 cells |
| Species | Human |
| Gene ID | 2305 |
| Uniprot | Q08050, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O08696, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P97691 |
| Cellular Localization | Nucleus. |
| Tissue Expression | Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis. |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Cellular senescence |
| Research Areas | >>Cellular senescence |
| Function | Alternative products:Isoform 1 and isoform 2 appear to be the only activators of gene transcription. Isoform 3, found in rat, does not seem to exist in human,developmental stage:Embryonic expression pattern: liver, lung, intestine, kidney, urinary tract; adult expression pattern: intestine, colon, testis and thymus.,Domain:Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4.,Function:Transcriptional activatory factor. May play a role in the control of cell proliferation.,induction:Induced during liver regeneration and oxidative stress.,PTM:Phosphorylated in M (mitotic) phase.,similarity:Contains 1 fork-head DNA-binding domain.,tissue specificity:Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells., |
