Fractalkine Receptor Polyclonal Antibody
Ucallm_WP15203-50
Price range: $268.00 through $328.00
Product details
Background:
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010],
Specifications
| Size | 50μL/100μL |
| Target | CX3CR1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 40kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from Fractalkine Receptor . at AA range: 120-200 |
| Specificity | Fractalkine Receptor Polyclonal Antibody detects endogenous levels of Fractalkine Receptor protein. |
| Gene Name | CX3CR1 |
| Protein Name | CX3C chemokine receptor 1 |
| Other Name | CX3CR1; / CMKBRL1; / GPR13; / CX3C chemokine receptor 1; / C-X3-C CKR-1; / CX3CR1; / Beta chemokine receptor-like 1; / CMK-BRL-1; / CMK-BRL1; / Fractalkine receptor; / G-protein coupled receptor 13; / V28 |
| Species | Human |
| Gene ID | 1524 |
| Uniprot | P49238, |
| Species.1 | Mouse |
| Gene ID.1 | 13051 |
| Uniprot.1 | Q9Z0D9, |
| Species.2 | Rat |
| Gene ID.2 | 171056 |
| Uniprot.2 | P35411 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Expressed in lymphoid and neural tissues (PubMed:7590284). Expressed in lymphocyte subsets, such as natural killer (NK) cells, gamma-delta T-cells and terminally differentiated CD8(+) T-cells (PubMed:12055230). Expressed in smooth muscle cells in atherosclerotic plaques (PubMed:14581400). |
| Signaling_pathway | Organismal Systems >> Immune system >> Chemokine signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>Chemokine signaling pathway |
| Function | Function:Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.,polymorphism:Variations in CX3CR1 are associated with rapid progression to AIDS [MIM:609423]. Increased susceptibility to HIV infection and rapid progression to AIDS are associated with the Ile-249/Met-280 haplotype.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with human respiratory syncytial virus (HRSV) protein G; this interaction modulates host immune response. Interacts with HIV-1 envelope polyprotein gp160.,tissue specificity:Expressed in lymphoid and neural tissues., |
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