Name: U-Blot® FRS2 Rabbit mAb
SKU: WR4689
Price: 268 USD
Availability: InStock

U-Blot® FRS2 Rabbit mAb

Western Blot analysis using SH-SY5Y lysates,primary antibody was diluted at 1:1000, 4°over night, Dylight 800 secondary antibody(WS0446)was diluted at 1:10000, 37° 1hour.

WR4689 Western Blot analysis using SH-SY5Y lysates,primary antibody was diluted at 1:1000, 4°over night, Dylight 800 secondary antibody(WS0446)was diluted at 1:10000, 37° 1hour.

Price range: $268.00 through $328.00

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100μl

50μl

Clear

SKU: WR4689-50

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Product details

Background:function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,

Specifications

Size	50μL/100μL
Target	FRS2
Reactivity	Human, Mouse, Rat
Applications	WB, IF, IP, ELISA
MW(Calculated)	57kD
MW(Observed)	80kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1008R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	FRS2
Protein Name	Fibroblast growth factor receptor substrate 2
Other Name	FRS2; / Fibroblast growth factor receptor substrate 2; / FGFR substrate 2; / FGFR-signaling adaptor SNT; / Suc1-associated neurotrophic factor target 1; / SNT-1
Species	Human
Gene ID	10818
Uniprot	Q8WU20,
Species.1	Mouse
Gene ID.1	327826
Uniprot.1	Q8C180
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Endomembrane system. Cytoplasmic, membrane-bound.
Tissue Expression	Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
Signaling_pathway	Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Research Areas	>>Thermogenesis; / >>Neurotrophin signaling pathway; / >>Proteoglycans in cancer
Function	Function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence Caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,

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U-Blot® FRS2 Rabbit mAb

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U-Blot® FRS2 Rabbit mAb

Product details

Specifications

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