Name: U-Blot® FTO Rabbit mAb
SKU: WR4209
Price: 268 USD
Availability: InStock

U-Blot® FTO Rabbit mAb

Western blot analysis of lysates from Jurkat cells, using FTO Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

WR4209 Western blot analysis of lysates from Jurkat cells, using FTO Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

Price range: $268.00 through $328.00

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100μl

50μl

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SKU: WR4209-50

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Product details

Background:This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011],

Specifications

Size	50μL/100μL
Target	FTO
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)	58kD
MW(Observed)	58kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:3000-1:20000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0383R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	FTO
Protein Name	Alpha-ketoglutarate-dependent dioxygenase FTO
Other Name	FTO; / KIAA1752; / Alpha-ketoglutarate-dependent dioxygenase FTO; / Fat mass and obesity-associated protein
Species	Human
Gene ID	79068
Uniprot	Q9C0B1,
Species.1	Mouse
Gene ID.1	26383
Uniprot.1	Q8BGW1,
Species.2	Rat
Gene ID.2	291905
Uniprot.2	Q2A121
Cellular Localization	Cytoplasm, Nucleus
Tissue Expression	Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary (PubMed:17434869, PubMed:17496892). Highly expressed in highly expressed in acute myeloid leukemias (AML) with t(11; 11)(q23; 23) with KMT2A/MLL1 rearrangements, t(15; 17)(q21; q21)/PML-RARA, FLT3-ITD, and/or NPM1 mutations (PubMed:28017614).
Signaling_pathway
Research Areas
Function	Function:The precise function of this protein remains to be determined.,polymorphism:At least one intronic variation within the gene predisposes to childhood and adult obesity.,similarity:Belongs to the fto family.,tissue specificity:Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.,

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U-Blot® FTO Rabbit mAb

Product details

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U-Blot® FTO Rabbit mAb

Product details

Specifications

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