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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/FXYD2 Polyclonal Antibody
SKU: WP16134 Categories: ,

FXYD2 Polyclonal Antibody

Ucallm_WP16134-50

Price range: $268.00 through $328.00

SKU: WP16134-100
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Product details

Background:

FXYD domain containing ion transport regulator 2(FXYD2) Homo sapiens This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011],

Specifications

Size50μL/100μL
TargetFXYD2
ReactivityHuman, Mouse, Rat
ApplicationsIHC, ELISA
MW(Calculated)
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:50-200; ELISA(peptide)1:5000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human FXYD2 AA range: 10-90
SpecificityThis antibody detects endogenous levels of human FXYD2
Gene NameFXYD2 ATP1C ATP1G1
Protein NameFXYD2
Other NameSodium/potassium-transporting ATPase subunit gamma; / Na; / +; / /K; / +; / ATPase subunit gamma; / FXYD domain-containing ion transport regulator 2; / Sodium pump gamma chain
SpeciesHuman
Gene ID486
UniprotP54710
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Single-pass type III membrane protein .
Tissue ExpressionExpressed in the distal convoluted tubule in the kidney. Found on basolateral membranes of nephron epithelial cells.
Signaling_pathwayOrganismal Systems >> Endocrine system >> Insulin secretion;Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway;Organismal Systems >> Circulatory system >> Cardiac muscle contraction;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway
Research Areas>>cGMP-PKG signaling pathway; / >>cAMP signaling pathway; / >>Cardiac muscle contraction; / >>Adrenergic signaling in cardiomyocytes; / >>Insulin secretion; / >>Thyroid hormone synthesis; / >>Thyroid hormone signaling pathway; / >>Aldosterone-regulated sodium reabsorption; / >>Endocrine and other factor-regulated calcium reabsorption; / >>Proximal tubule bicarbonate reclamation; / >>Salivary secretion; / >>Pancreatic secretion; / >>Carbohydrate digestion and absorption; / >>Protein digestion and absorption; / >>Bile secretion; / >>Mineral absorption
FunctionDisease:Defects in FXYD2 are the cause of hypomagnesemia type 2 (HOMG2) [MIM:154020]; also known as dominant renal hypomagnesemia or hypomagnesemia with hypocalciuria. HOMG2 is a disorder due to primary renal wasting of magnesium. Plasma levels of other electrolytes are normal. The only abnormality found, in addition to low magnesium levels, is lowered renal excretion of calcium resulting in hypocalciuria.,Function:May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.,sequence Caution:Wrong choice of frame.,similarity:Belongs to the FXYD family.,subunit:Composed of three subunits: alpha (catalytic), beta and gamma.,tissue specificity:Expressed in the distal convoluted tubule in the kidney. Found on basolateral membranes of nephron epithelial cells.,
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