SKU: WP16271 Categories: ,

FXYD3 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP16271-100
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Product details

Background:

This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008],

Specifications

Size50μL/100μL
TargetFXYD3
ReactivityHuman, Mouse, Rat
ApplicationsIHC, IF
MW(Calculated)10kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:50-200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human FXYD3 AA range: 15-65
SpecificityThis antibody detects endogenous levels of FXYD3 at Human/Mouse/Rat
Gene NameFXYD3 MAT8 PLML
Protein NameFXYD3
Other Name
SpeciesHuman
Gene ID5349
UniprotQ14802,
Species.1Mouse
Gene ID.117178
Uniprot.1Q61835,
Species.2Rat
Gene ID.2116831
Uniprot.2P59645
Cellular LocalizationCell membrane; Single-pass type I membrane protein .
Tissue ExpressionIsoform 1: Expressed mainly in differentiated cells (at protein level). Isoform 2: Expressed mainly in undifferentiated cells (at protein level).
Signaling_pathway
Research Areas
FunctionFunction:Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels.,miscellaneous:Marker of a cell type preferentially transformed by neu or ras oncoprotein.,similarity:Belongs to the FXYD family.,tissue specificity:Expressed in a subset of human breast tumors.,
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