Name: Gα i-3 Polyclonal Antibody
SKU: WP12636
Price: 268 USD
Availability: InStock

Product details

Background:

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012],

Specifications

Target	GNAI3
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	41kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human GNAI3. AA range:31-80
Sequence
Specificity	Gα i-3 Polyclonal Antibody detects endogenous levels of Gα i-3 protein.
Gene Name	GNAI3
Protein Name	Guanine nucleotide-binding protein G(k) subunit alpha
Other Name	GNAI3; / Guanine nucleotide-binding protein G; / k; / subunit alpha; / G; / i; / alpha-3
Species	Human
Gene ID-1	2773
Uniprot	P08754,
Species.1	Mouse
Gene ID-2	14679
Uniprot.1	Q9DC51,
Species.2	Rat
Gene ID-3	25643
Uniprot.2	P08753
Organism-4
Gene ID-4
SwissProt-4
Background	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012],
Cellular Localization	Cytoplasm . Cell membrane; Lipid-anchor . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. .
Tissue Expression	Liver,
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Gap junction;Organismal Systems >> Immune system >> Platelet activation;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Organismal Systems >> Immune system >> Chemokine signaling pathway;Organismal Systems >> Endocrine system >> Estrogen signaling pathway;Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Organismal Systems >> Endocrine system >> Relaxin signaling pathway;Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Organismal Systems >> Nervous system >> Glutamatergic synapse;Organismal Systems >> Nervous system >> Cholinergic synapse;Organismal Systems >> Nervous system >> Dopaminergic synapse;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway;Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway
Research Areas	>>Rap1 signaling pathway; / >>cGMP-PKG signaling pathway; / >>cAMP signaling pathway; / >>Chemokine signaling pathway; / >>Sphingolipid signaling pathway; / >>Adrenergic signaling in cardiomyocytes; / >>Axon guidance; / >>Apelin signaling pathway; / >>Gap junction; / >>Platelet activation; / >>Leukocyte transendothelial migration; / >>Circadian entrainment; / >>Retrograde endocannabinoid signaling; / >>Glutamatergic synapse; / >>Cholinergic synapse; / >>Serotonergic synapse; / >>GABAergic synapse; / >>Dopaminergic synapse; / >>Long-term depression; / >>Progesterone-mediated oocyte maturation; / >>Estrogen signaling pathway; / >>Melanogenesis; / >>Oxytocin signaling pathway; / >>Regulation of lipolysis in adipocytes; / >>Renin secretion; / >>Relaxin signaling pathway; / >>Parathyroid hormone synthesis, secretion and action; / >>Cushing syndrome; / >>Growth hormone synthesis, secretion and action; / >>Gastric acid secretion; / >>Parkinson disease; / >>Cocaine addiction; / >>Morphine addiction; / >>Alcoholism; / >>Pertussis; / >>Chagas disease; / >>Toxoplasmosis; / >>Human cytomegalovirus infection; / >>Human immunodeficiency virus 1 infection; / >>Pathways in cancer; / >>Chemical carcinogenesis - receptor activation
Function	Function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K(+) channels.,similarity:Belongs to the G-alpha family. G(i/o/t/z) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1.,
RRID

Please login to post questions

Gα i-3 Polyclonal Antibody

Product details

Specifications

About Us

Support

Order

Menu

Gα i-3 Polyclonal Antibody

Product details

Specifications

Related products

U-Blot™ Universal Antibody Dilution Buffer

U-Blot® CDC37 (Phospho Ser13) Rabbit mAb

U-Blot® VEGF Receptor 1 Rabbit mAb

U-Blot® CDK6 Rabbit mAb

U-Blot™ Phosphate Buffered Saline with Tween 20 (PBS-T), pH 7.4

Acetyl Lysine Monoclonal Antibody [10B10]

Customer Reviews

Menu