Price range: $268.00 through $328.00
Background:
GRB2 associated binding protein 1(GAB1) Homo sapiens The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
| Size | 50μL/100μL |
| Target | Gab 1 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| MW(Calculated) | |
| MW(Observed) | 76kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-300; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Recombinant Protein of Gab1 |
| Specificity | The antibody detects endogenous Gab1 protein |
| Gene Name | GAB1 |
| Protein Name | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) |
| Other Name | GRB2-associated-binding protein 1; / GRB2-associated binder 1; / Growth factor receptor bound protein 2-associated protein 1 |
| Species | Human |
| Gene ID | 2549 |
| Uniprot | Q13480, |
| Species.1 | Mouse |
| Gene ID.1 | 14388 |
| Uniprot.1 | Q9QYY0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | cytosol, |
| Tissue Expression | Testis,Whole embryo, |
| Signaling_pathway | Organismal Systems >> Nervous system >> Neurotrophin signaling pathway;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Renal cell carcinoma;Environmental Information Processing >> Signal transduction >> ErbB signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway |
| Research Areas | >>EGFR tyrosine kinase inhibitor resistance; / >>ErbB signaling pathway; / >>Ras signaling pathway; / >>Phospholipase D signaling pathway; / >>Neurotrophin signaling pathway; / >>Bacterial invasion of epithelial cells; / >>Proteoglycans in cancer; / >>Renal cell carcinoma; / >>Hepatocellular carcinoma; / >>Gastric cancer |
| Function | Function:Probably involved in EGF and insulin receptor signaling.,PTM:Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2., |
