Product details
Background:
The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009],
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GABA T-1 Polyclonal Antibody
Ucallm_WP15799-50
Price range: $268.00 through $328.00
Specifications
| Target | GABA T-1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 50kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human SLC6A1. AA range:170-220 |
| Sequence | |
| Specificity | The antibody detects endogenous GABA T-1 |
| Gene Name | SLC6A1 GABATR GABT1 GAT1 |
| Protein Name | Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) |
| Other Name | Sodium- and chloride-dependent GABA transporter 1; / GAT-1; / Solute carrier family 6 member 1 |
| Species | Human |
| Gene ID-1 | 6529 |
| Uniprot | P30531, |
| Species.1 | Mouse |
| Gene ID-2 | 232333 |
| Uniprot.1 | P31648, |
| Species.2 | Rat |
| Gene ID-3 | 79212 |
| Uniprot.2 | P23978 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009], |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Cell junction, synapse, presynapse . Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity). . |
| Tissue Expression | Brain, |
| Signaling_pathway | Organismal Systems >> Nervous system >> Synaptic vesicle cycle |
| Research Areas | >>Synaptic vesicle cycle; / >>GABAergic synapse |
| Function | Domain:The PDZ domain-binding motif is involved in the interaction with MPP5.,Function:Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.,miscellaneous:This protein is the target of psychomotor stimulants such as amphetamines or cocaine.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,subcellular location:Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons.,subunit:Interacts with MPP5., |
| RRID |
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