Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which ends the GABA neurotransmission. Defects in this gene may result in epilepsy, behavioral problems, or intellectual problems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],
| Target | GABA T-3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 70kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from GABA T-3 . at AA range: 370-450 |
| Sequence | |
| Specificity | GABA T-3 Polyclonal Antibody detects endogenous levels of GABA T-3 protein. |
| Gene Name | SLC6A11 |
| Protein Name | Sodium- and chloride-dependent GABA transporter 3 |
| Other Name | SLC6A11; / GABT3; / GAT3; / Sodium- and chloride-dependent GABA transporter 3; / GAT-3; / Solute carrier family 6 member 11 |
| Species | Human |
| Gene ID-1 | 6538 |
| Uniprot | P48066, |
| Species.1 | Mouse |
| Gene ID-2 | 243616 |
| Uniprot.1 | P31650, |
| Species.2 | Rat |
| Gene ID-3 | 79213 |
| Uniprot.2 | P31647 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | The protein encoded by this gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which ends the GABA neurotransmission. Defects in this gene may result in epilepsy, behavioral problems, or intellectual problems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015], |
| Cellular Localization | Membrane; Multi-pass membrane protein. |
| Tissue Expression | Widespread distribution in the brain. |
| Signaling_pathway | Organismal Systems >> Nervous system >> Synaptic vesicle cycle |
| Research Areas | >>Synaptic vesicle cycle; / >>GABAergic synapse |
| Function | Function:Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,tissue specificity:Widespread distribution in the brain., |
| RRID |
