Price range: $268.00 through $328.00
Background:
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008],
| Target | GABAA Rα6 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 51kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GABRA6. AA range:61-110 |
| Sequence | |
| Specificity | GABAA Rα6 Polyclonal Antibody detects endogenous levels of GABAA Rα6 protein. |
| Gene Name | GABRA6 |
| Protein Name | Gamma-aminobutyric acid receptor subunit alpha-6 |
| Other Name | GABRA6; / Gamma-aminobutyric acid receptor subunit alpha-6; / GABA; / A; / receptor subunit alpha-6 |
| Species | Human |
| Gene ID-1 | 2559 |
| Uniprot | Q16445, |
| Species.1 | Mouse |
| Gene ID-2 | 14399 |
| Uniprot.1 | P16305, |
| Species.2 | Rat |
| Gene ID-3 | 29708 |
| Uniprot.2 | P30191 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008], |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Cerebellum, |
| Signaling_pathway | |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Retrograde endocannabinoid signaling; / >>GABAergic synapse; / >>Taste transduction; / >>Morphine addiction; / >>Nicotine addiction |
| Function | Function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho., |
| RRID |
