Price range: $268.00 through $328.00
Background:
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | GABAA Rβ1 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GABA-RB. AA range:401-450 |
| Specificity | GABAA Rβ1 Polyclonal Antibody detects endogenous levels of GABAA Rβ1 protein. |
| Gene Name | GABRB1 |
| Protein Name | Gamma-aminobutyric acid receptor subunit beta-1 |
| Other Name | GABRB1; / Gamma-aminobutyric acid receptor subunit beta-1; / GABA; / A; / receptor subunit beta-1 |
| Species | Human |
| Gene ID | 2560 |
| Uniprot | P18505, |
| Species.1 | Mouse |
| Gene ID.1 | 14400 |
| Uniprot.1 | P50571, |
| Species.2 | Rat |
| Gene ID.2 | 25450 |
| Uniprot.2 | P15431 |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein . Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Brain,Epithelium, |
| Signaling_pathway | |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Retrograde endocannabinoid signaling; / >>Serotonergic synapse; / >>GABAergic synapse; / >>Morphine addiction; / >>Nicotine addiction |
| Function | Function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho., |
