Price range: $268.00 through $328.00
Background:
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008],
| Target | GALR1 |
| Reactivity | Human, Mouse |
| Applications | IF, ELISA |
| MW(Calculated) | 39kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications; |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GALR1. AA range:161-210 |
| Sequence | |
| Specificity | GALR1 Polyclonal Antibody detects endogenous levels of GALR1 protein. |
| Gene Name | GALR1 |
| Protein Name | Galanin receptor type 1 |
| Other Name | GALR1; / GALNR; / GALNR1; / Galanin receptor type 1; / GAL1-R; / GALR-1 |
| Species | Human |
| Gene ID-1 | 2587 |
| Uniprot | P47211, |
| Species.1 | Mouse |
| Gene ID-2 | 14427 |
| Uniprot.1 | P56479 |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008], |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Brain,Melanoma,Small intestine, |
| Signaling_pathway | |
| Research Areas | >>Neuroactive ligand-receptor interaction |
| Function | Function:Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.,PTM:Palmitoylated on at least one of the three cysteine residues present in the C-terminal part.,similarity:Belongs to the G-protein coupled receptor 1 family., |
| RRID |
