GALR2 Polyclonal Antibody
Ucallm_WP12417-50
Price range: $268.00 through $328.00
Product details
Background:
Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simul
Specifications
| Size | 50μL/100μL |
| Target | GALR2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 42kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GALR2. AA range:201-250 |
| Specificity | GALR2 Polyclonal Antibody detects endogenous levels of GALR2 protein. |
| Gene Name | GALR2 |
| Protein Name | Galanin receptor type 2 |
| Other Name | GALR2; / GALNR2; / Galanin receptor type 2; / GAL2-R; / GALR-2 |
| Species | Human |
| Gene ID | 8811 |
| Uniprot | O43603, |
| Species.1 | Mouse |
| Gene ID.1 | 14428 |
| Uniprot.1 | O88854, |
| Species.2 | Rat |
| Gene ID.2 | 29234 |
| Uniprot.2 | O08726 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine. |
| Signaling_pathway | |
| Research Areas | >>Neuroactive ligand-receptor interaction |
| Function | Function:Receptor for the hormone galanin and for GALP. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via Gq) and that inhibit adenylyl cyclase (via Gi).,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine., |
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