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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/GALT2 rabbit pAb
SKU: WP3601 Categories: ,

GALT2 rabbit pAb

Ucallm_WP3601-50

Price range: $268.00 through $328.00

SKU: WP3601-100
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Product details

Background:

This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],

Specifications

Size50μL/100μL
TargetGALT2
ReactivityHuman, Mouse
ApplicationsWB
MW(Calculated)
MW(Observed)65kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human GALT2 AA range: 30-80
SpecificityThis antibody detects endogenous levels of GALT2 at Human/Mouse
Gene NameGALNT2
Protein NameGALT2
Other NamePolypeptide N-acetylgalactosaminyltransferase 2; / Polypeptide GalNAc transferase 2; / GalNAc-T2; / pp-GaNTase 2; / Protein-UDP acetylgalactosaminyltransferase 2; / UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2; / [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form]
SpeciesHuman
Gene ID2590
UniprotQ10471,
Species.1Mouse
Gene ID.1108148
Uniprot.1Q6PB93
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationGolgi apparatus, Golgi stack membrane; Single-pass type II membrane protein . Secreted . Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.
Tissue ExpressionWidely expressed.
Signaling_pathway
Research Areas>>Mucin type O-glycan biosynthesis; / >>Other types of O-glycan biosynthesis; / >>Metabolic pathways
FunctionCatalytic activity:UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide.,cofactor:Calcium.,cofactor:Manganese.,Domain:The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.,Domain:There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.,Function:Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.,online information:GlycoGene database,online information:Polypeptide N-acetylgalactosaminyltransferase 2,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.,similarity:Contains 1 ricin B-type lectin domain.,subcellular location:Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.,tissue specificity:Widely expressed.,
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