Name: GATA-4 Monoclonal Antibody
SKU: WM0211
Price: 268 USD
Availability: InStock

GATA-4 Monoclonal Antibody

Ucallm_WM0211-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WM0211-50

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Product details

Background:
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],

Specifications

Size	50μL/100μL
Target	GATA-4
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)	45kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	7A10
Immunogen	Purified recombinant fragment of human GATA-4 expressed in E. Coli.
Specificity	GATA-4 Monoclonal Antibody detects endogenous levels of GATA-4 protein.
Gene Name	GATA4
Protein Name	Transcription factor GATA-4
Other Name	GATA4; / Transcription factor GATA-4; / GATA-binding factor 4
Species	Human
Gene ID	2626
Uniprot	P43694,
Species.1	Mouse
Gene ID.1	14463
Uniprot.1	Q08369
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus .
Tissue Expression	Heart,Lung,
Signaling_pathway	Cellular Processes >> Cell growth and death >> Cellular senescence;Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway
Research Areas	>>cGMP-PKG signaling pathway; / >>Cellular senescence; / >>Tight junction; / >>Thyroid hormone signaling pathway
Function	Disease:Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.,Function:Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5.,similarity:Contains 2 GATA-type zinc fingers.,subunit:Interacts with ZNF260 (By similarity). Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4.,