Name: GBLP Polyclonal Antibody
SKU: WP2521
Price: 268 USD
Availability: InStock

Product details

Background:

domain:The WD repeats domain 5 mediates interaction with TRIM63., function:Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation., similarity:Belongs to the WD repeat G protein beta family., similarity:Contains 7 WD repeats., subcellular location:Located on plasma membrane of neuroblastoma NMB7 cells., subunit:Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and KRT1.,

Specifications

Target	RACK1
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	34kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from part region of human protein. AA range:19-69
Sequence
Specificity	GBLP Polyclonal Antibody detects endogenous levels of protein.
Gene Name	GNB2L1 HLC7 PIG21
Protein Name	Guanine nucleotide-binding protein subunit beta-2-like 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) (RACK1)
Other Name
Species	Human
Gene ID-1	10399
Uniprot	P63244,
Species.1	Mouse
Gene ID-2
Uniprot.1	P68040,
Species.2	Rat
Gene ID-3
Uniprot.2	P63245
Organism-4
Gene ID-4
SwissProt-4
Background	domain:The WD repeats domain 5 mediates interaction with TRIM63. ,function:Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1 , serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation. ,similarity:Belongs to the WD repeat G protein beta family. ,similarity:Contains 7 WD repeats. ,subcellular location:Located on plasma membrane of neuroblastoma NMB7 cells. ,subunit:Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and KRT1. ,
Cellular Localization	Cell membrane; Peripheral membrane protein. Cytoplasm . Cytoplasm , perinuclear region . Nucleus . Perikaryon . Cell projection , dendrite . Cell projection , phagocytic cup . Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1 (PubMed:17956333) . Also associated with the membrane in oncogene-transformed cells (PubMed:11884618) . PKC activation induces translocation from the perinuclear region to the cell periphery (PubMed:11279199) . In the brain , detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity) . Localized to phagocytic cups following infection by Y.pestis (PubMed:21347310) . .
Tissue Expression	In the liver , expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue.
Signaling_pathway
Research Areas	>>Measles
Function	Domain:The WD repeats domain 5 mediates interaction with TRIM63. ,Function:Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1 , serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation. ,similarity:Belongs to the WD repeat G protein beta family. ,similarity:Contains 7 WD repeats. ,subcellular location:Located on plasma membrane of neuroblastoma NMB7 cells. ,subunit:Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and KRT1. ,
RRID

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GBLP Polyclonal Antibody

Product details

Specifications

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GBLP Polyclonal Antibody

Product details

Specifications

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