GBLP Polyclonal Antibody
Ucallm_WP2521-50
Price range: $268.00 through $328.00
Product details
Background:
domain:The WD repeats domain 5 mediates interaction with TRIM63., function:Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation., similarity:Belongs to the WD repeat G protein beta family., similarity:Contains 7 WD repeats., subcellular location:Located on plasma membrane of neuroblastoma NMB7 cells., subunit:Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and KRT1.,
Specifications
| Size | 50μL/100μL |
| Target | RACK1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 34kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year (Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein. AA range:19-69 |
| Specificity | GBLP Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | GNB2L1 HLC7 PIG21 |
| Protein Name | Guanine nucleotide-binding protein subunit beta-2-like 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) (RACK1) |
| Other Name | |
| Species | Human |
| Gene ID | 10399 |
| Uniprot | P63244, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P68040, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P63245 |
| Cellular Localization | Cell membrane; Peripheral membrane protein. Cytoplasm . Cytoplasm , perinuclear region . Nucleus . Perikaryon . Cell projection , dendrite . Cell projection , phagocytic cup . Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1 (PubMed:17956333) . Also associated with the membrane in oncogene-transformed cells (PubMed:11884618) . PKC activation induces translocation from the perinuclear region to the cell periphery (PubMed:11279199) . In the brain , detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity) . Localized to phagocytic cups following infection by Y.pestis (PubMed:21347310) . . |
| Tissue Expression | In the liver , expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue. |
| Signaling_pathway | |
| Research Areas | >>Measles |
| Function | Domain:The WD repeats domain 5 mediates interaction with TRIM63. ,Function:Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1 , serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation. ,similarity:Belongs to the WD repeat G protein beta family. ,similarity:Contains 7 WD repeats. ,subcellular location:Located on plasma membrane of neuroblastoma NMB7 cells. ,subunit:Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and KRT1. , |
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