Price range: $268.00 through $328.00
Background:
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012],
| Size | 50μL/100μL |
| Target | GBRR1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 52kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | GBRR1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | GABRR1 |
| Protein Name | Gamma-aminobutyric acid receptor subunit rho-1 (GABA(A) receptor subunit rho-1) (GABA(C) receptor) |
| Other Name | |
| Species | Human |
| Gene ID | 2569 |
| Uniprot | P24046, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P56475, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P50572 |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Highly expressed in the retina and in a lesser extent in brain, lung and thymus. |
| Signaling_pathway | |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Retrograde endocannabinoid signaling; / >>GABAergic synapse; / >>Morphine addiction; / >>Nicotine addiction |
| Function | Function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.,tissue specificity:Highly expressed in the retina and in a lesser extent in brain, lung and thymus., |
