Product details
Background:
GCAP2 rabbit pAb
Ucallm_WP7982-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | GUCA1B |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 22kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human GCAP2 |
| Specificity | This antibody detects endogenous levels of GCAP2 at Human, Mouse |
| Gene Name | GUCA1B GCAP2 |
| Protein Name | Guanylyl cyclase-activating protein 2 (GCAP 2) (Guanylate cyclase activator 1B) |
| Other Name | |
| Species | Human |
| Gene ID | 2979 |
| Uniprot | Q9UMX6, |
| Species.1 | Mouse |
| Gene ID.1 | 107477 |
| Uniprot.1 | Q8VBV8 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Lipid-anchor . Photoreceptor inner segment . Cell projection, cilium, photoreceptor outer segment . Subcellular location is not affected by light or dark conditions. . |
| Tissue Expression | In the retina, it is expressed in cone and rod photoreceptor cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity). |
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