Price range: $268.00 through $328.00
Background:
Nitric oxide-sensitive guanylyl cyclase is a heterodimeric enzyme consisting of an alpha and a beta subunit. The enzyme converts GTP into the second messenger cGMP and plays a major role in the cardiovascular system as a receptor for nitric oxide. Unlike other guanylyl cyclases, GUCY1B2 contains an 86-amino acid C-terminal extension with a consensus sequence for isoprenylation/carboxymethylation.
| Size | 50μL/100μL |
| Target | GCS-β-2 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 70kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GCS-beta-2. AA range:53-102 |
| Specificity | GCS-β-2 Polyclonal Antibody detects endogenous levels of GCS-β-2 protein. |
| Gene Name | GUCY1B2 |
| Protein Name | Guanylate cyclase soluble subunit beta-2 |
| Other Name | GUCY1B2; / Guanylate cyclase soluble subunit beta-2; / GCS-beta-2 |
| Species | Human |
| Gene ID | 2974 |
| Uniprot | O75343, |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | 25206 |
| Uniprot.2 | P22717 |
| Cellular Localization | Cytoplasm. |
| Tissue Expression | Expressed in gastric signet ring cell carcinoma, but not in the normal stomach. |
| Signaling_pathway | |
| Research Areas | |
| Function |
