Price range: $268.00 through $328.00
Background:
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
| Target | GELS |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 86kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Sequence | |
| Specificity | GELS Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | GSN |
| Protein Name | Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin) |
| Other Name | |
| Species | Human |
| Gene ID-1 | 2934 |
| Uniprot | P06396, |
| Species.1 | Mouse |
| Gene ID-2 | |
| Uniprot.1 | P13020, |
| Species.2 | Rat |
| Gene ID-3 | |
| Uniprot.2 | Q68FP1 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | The protein encoded by this gene binds to the " plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Cellular Localization | [Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 1]: Secreted. |
| Tissue Expression | Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells. |
| Signaling_pathway | Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis |
| Research Areas | >>Fc gamma R-mediated phagocytosis; / >>Regulation of actin cytoskeleton; / >>Viral carcinogenesis |
| Function | Disease:Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.,Function:Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.,online information:Gelsolin entry,PTM:Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.,similarity:Belongs to the villin/gelsolin family.,similarity:Contains 6 gelsolin-like repeats.,subunit:Binds to actin and to fibronectin.,tissue specificity:Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells., |
| RRID |
