Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010],
| Size | 50μL/100μL |
| Target | GEMI8 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 26kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 180-260 |
| Specificity | GEMI8 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | GEMIN8 FAM51A1 |
| Protein Name | Gem-associated protein 8 (Gemin-8) (Protein FAM51A1) |
| Other Name | |
| Species | Human |
| Gene ID | 54960 |
| Uniprot | Q9NWZ8, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BHE1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus, gem . Cytoplasm . Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm. |
| Tissue Expression | Colon,Gastric carcinoma,Lung,Thalamus, |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.,subcellular location:Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.,subunit:Part of the core SMN complex that contains SMN1, SIP1/GEMIN2, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to SMN1 and to the GEMIN6-GEMIN7 heterodimer, mediating their interaction., |
