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GIYD2 rabbit pAb
Ucallm_WP6860-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | SLX1A; SLX1B |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 30kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human GIYD2 |
| Specificity | This antibody detects endogenous levels of GIYD2 at Human, Mouse,Rat |
| Gene Name | SLX1A GIYD1 SLX1; SLX1B GIYD2 SLX1 |
| Protein Name | Structure-specific endonuclease subunit SLX1 (GIY-YIG domain-containing protein 1) |
| Other Name | |
| Species | Human |
| Gene ID | 548593 |
| Uniprot | Q9BQ83, |
| Species.1 | Mouse |
| Gene ID.1 | 75764 |
| Uniprot.1 | Q8BX32, |
| Species.2 | Rat |
| Gene ID.2 | 293489 |
| Uniprot.2 | Q5PQP5 |
| Cellular Localization | Nucleus . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. |
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