Name: GKLF Monoclonal Antibody
SKU: WM0217
Price: 268 USD
Availability: InStock

GKLF Monoclonal Antibody

Ucallm_WM0217-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WM0217-50

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Product details

Background:
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	KLF4
Reactivity	Human
Applications	WB, IHC, IF, ELISA
MW(Calculated)	55kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	1A5
Immunogen	Purified recombinant fragment of human GKLF expressed in E. Coli.
Specificity	GKLF Monoclonal Antibody detects endogenous levels of GKLF protein.
Gene Name	KLF4
Protein Name	Krueppel-like factor 4
Other Name	KLF4; / EZF; / GKLF; / Krueppel-like factor 4; / Epithelial zinc finger protein EZF; / Gut-enriched krueppel-like factor
Species	Human
Gene ID	9314
Uniprot	O43474,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q60793
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nuclear
Tissue Expression	Cervix,Lung,Placenta,Substantia nigra,Tongue,
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells
Research Areas	>>Signaling pathways regulating pluripotency of stem cells; / >>Chemical carcinogenesis - receptor activation
Function	Function:Transcription factor which acts as both an activator and repressor. Binds the CACCC core sequence. Binds to multiple sites in the 5'-flanking region of its own gene and can activate its own transcription. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interaction with the C-terminal domain of MUC1 enhances suppression of TP53/p53 transcription.,