Product details
Background:
GLRX2 rabbit pAb
Ucallm_WP6379-50
Price range: $268.00 through $328.00
Specifications
| Target | GLRX2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 18kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human GLRX2 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of GLRX2 at Human, Mouse,Rat |
| Gene Name | GLRX2 GRX2 CGI-133 |
| Protein Name | Glutaredoxin-2, mitochondrial |
| Other Name | |
| Species | Human |
| Gene ID-1 | 51022 |
| Uniprot | Q9NS18, |
| Species.1 | Mouse |
| Gene ID-2 | 69367 |
| Uniprot.1 | Q923X4, |
| Species.2 | Rat |
| Gene ID-3 | 114022 |
| Uniprot.2 | Q6AXW1 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | |
| Cellular Localization | [Isoform 1]: Mitochondrion.; [Isoform 2]: Nucleus. |
| Tissue Expression | Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes. |
| Signaling_pathway | |
| Research Areas | |
| Function | Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. |
| RRID |
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