Price range: $268.00 through $328.00
Background:
Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010],
| Size | 50μL/100μL |
| Target | GNDS |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 100kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 130-210 |
| Specificity | GNDS Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | RALGDS KIAA1308 RGF |
| Protein Name | Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF) |
| Other Name | |
| Species | Human |
| Gene ID | 5900 |
| Uniprot | Q12967, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q03385, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q03386 |
| Cellular Localization | Cytoplasm . Nucleus . Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage. Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger. After the 4-cell stage, not detected in the nucleus. . |
| Tissue Expression | Brain,Epithelium,Placenta,Primary B-Cells,Spleen,Thalamus, |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Colorectal cancer;Human Diseases >> Cancer: specific types >> Pancreatic cancer;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway |
| Research Areas | >>Ras signaling pathway; / >>Rap1 signaling pathway; / >>Phospholipase D signaling pathway; / >>Pathways in cancer; / >>Colorectal cancer; / >>Pancreatic cancer; / >>Choline metabolism in cancer |
| Function | Domain:The Ras-associating domain interacts with Ras.,Function:Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 Ras-GEF domain.,subunit:Interacts with RIT1 and RIT2., |
