SKU: WP2487 Categories: ,

GNLY Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP2487-100
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Product details

Background:

The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetGNLY
ReactivityHuman
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)15kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityGNLY Polyclonal Antibody detects endogenous levels of protein.
Gene NameGNLY LAG2 NKG5 TLA519
Protein NameGranulysin (Lymphokine LAG-2) (Protein NKG5) (T-cell activation protein 519)
Other Name
SpeciesHuman
Gene ID10578
UniprotP22749
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationSecreted. Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.
Tissue ExpressionExpressed in natural killer and T-cells.
Signaling_pathway
Research Areas
FunctionFunction:Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.,induction:By T-cell growth factor and interleukin-2.,PTM:A 9 kDa form is produced by proteolytic processing of a 15 kDa protein.,similarity:Contains 1 saposin B-type domain.,subcellular location:Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.,tissue specificity:Expressed in natural killer and T-cells.,
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