Name: U-Blot® GPER1 Rabbit mAb
SKU: WR4480
Price: 268 USD
Availability: InStock

U-Blot® GPER1 Rabbit mAb

Mouse brain whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with primary antibody(1:1000). The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.

WR4480 Mouse brain whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with primary antibody(1:1000). The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR4480-50

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Product details

Background:This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	GPER1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)	42kD
MW(Observed)	55kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:1000-1:5000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0701R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	GPER CEPR CMKRL2 DRY12 GPR30
Protein Name	G-protein coupled estrogen receptor 1
Other Name	G-protein coupled estrogen receptor 1; / Chemoattractant receptor-like 2; / Flow-induced endothelial G-protein coupled receptor 1; / FEG-1; / G-protein coupled receptor 30; / GPCR-BR; / IL8-related receptor DRY12; / Lymphocyte-derived G-protein coupled receptor; / LYGPR; / Membrane estrogen receptor; / mER
Species	Human
Gene ID	2852
Uniprot	Q99527,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q8BMP4,
Species.2	Rat
Gene ID.2
Uniprot.2	O08878
Cellular Localization	Membrane
Tissue Expression	Expressed in placenta, endothelial and epithelial cells, non laboring and laboring term myometrium, fibroblasts and cancer-associated fibroblasts (CAF), prostate cancer cells and invasive adenocarcinoma (at protein level). Ubiquitously expressed, but is most abundant in placenta. In brain regions, expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen.
Signaling_pathway	Organismal Systems >> Endocrine system >> Estrogen signaling pathway
Research Areas	>>Endocrine resistance; / >>Estrogen signaling pathway; / >>GnRH secretion
Function	Function:Receptor for estrogen.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Protein has been detected in the cell membrane, endoplasmic reticulum and Golgi apparatus. It is currently unclear whether this is a cell surface or intracellular receptor.,tissue specificity:Ubiquitously expressed, but is most abundant in placenta. In brain regions, expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen.,