Name: GST-Pi [ABT-GSTP1] mouse mAb
SKU: WM1497
Price: 268 USD
Availability: InStock

GST-Pi [ABT-GSTP1] mouse mAb

Ucallm_WM1497-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WM1497-50

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Product details

Background:
GST -Pi is a major isoenzyme in GST family. It widely exists in the cytoplasm and mitochondria of human organs and has detoxification function. At present, it is considered to be a marker of drug resistance in tumor cells. GST – Pi is highly expressed in a variety of tumors, which is related to tumor treatment drug resistance. The simultaneous detection of GST – Pi with P-gp and TopoII has more clinical significance for judging whether tumor cells produce drug resistance.

Specifications

Size	50μL/100μL
Target	GST-Pi
Reactivity	Human
Applications	IHC, WB, IF, ELISA
MW(Calculated)	23kD
MW(Observed)	26kD
Host Species	Mouse
Isotype	IgG1,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RMM-GSTP1
Immunogen	Synthesized peptide derived from human GST-Pi AA range: 150-210
Specificity	The antibody can specifically recognize human GST-Pi protein. In western blotting of Hela cell lysate, the antibody can label a 26 kDa band corresponding to GST-Pi.
Gene Name	GSTP1 FAEES3 GST3
Protein Name	Deafness; Deafness X-linked 7; DFN7; FAEES3; Fatty Acid Ethyl Ester Synthase III; Glutathione S Transferase 3; Glutathione S Transferase Pi; Glutathione S-transferase P; Glutathione S-transferase pi 1; GST class-pi; GST3; GSTP; Gstp1; GSTP1-1; GSTP1_HUMAN; PI; X linked 7
Other Name	GSTP1 FAEES3 GST3
Species	Human
Gene ID	2950
Uniprot	P09211,
Species.1	Mouse
Gene ID.1
Uniprot.1	P19157,
Species.2	Rat
Gene ID.2
Uniprot.2	P04906
Cellular Localization	Cytoplasmic
Tissue Expression	Esophageal squamous cell carcinoma
Signaling_pathway	Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma;Human Diseases >> Cancer: specific types >> Prostate cancer
Research Areas	>>Glutathione metabolism; / >>Metabolism of xenobiotics by cytochrome P450; / >>Drug metabolism - cytochrome P450; / >>Drug metabolism - other enzymes; / >>Metabolic pathways; / >>Platinum drug resistance; / >>Pathways in cancer; / >>Chemical carcinogenesis - DNA adducts; / >>Prostate cancer; / >>Hepatocellular carcinoma; / >>Fluid shear stress and atherosclerosis
Function	Catalytic activity:RX + glutathione = HX + R-S-glutathione.,Function:Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the GST superfamily. Pi family.,similarity:Contains 1 GST C-terminal domain.,similarity:Contains 1 GST N-terminal domain.,subunit:Homodimer.,