Name: GSTP1 Monoclonal Antibody
SKU: WM0227
Price: 268 USD
Availability: InStock

GSTP1 Monoclonal Antibody

Ucallm_WM0227-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WM0227-50

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Product details

Background:
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	GST-Pi
Reactivity	Human
Applications	WB, IHC, IF, FC, ELISA
MW(Calculated)	23kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	17D1
Immunogen	Purified recombinant fragment of human GST-Pi expressed in E. Coli.
Specificity	GST-Pi Monoclonal Antibody detects endogenous levels of GSTP1 protein.
Gene Name	GSTP1
Protein Name	Glutathione S-transferase P
Other Name	GSTP1; / FAEES3; / GST3; / Glutathione S-transferase P; / GST class-pi; / GSTP1-1
Species	Human
Gene ID	2950
Uniprot	P09211,
Species.1	Mouse
Gene ID.1
Uniprot.1	P19157
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm . Mitochondrion . Nucleus . The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.
Tissue Expression	Brain,Cajal-Retzius cell,Colon carcinoma,Fetal brain cortex,Platelet,Urinar
Signaling_pathway	Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma;Human Diseases >> Cancer: specific types >> Prostate cancer
Research Areas	>>Glutathione metabolism; / >>Metabolism of xenobiotics by cytochrome P450; / >>Drug metabolism - cytochrome P450; / >>Drug metabolism - other enzymes; / >>Metabolic pathways; / >>Platinum drug resistance; / >>Pathways in cancer; / >>Chemical carcinogenesis - DNA adducts; / >>Prostate cancer; / >>Hepatocellular carcinoma; / >>Fluid shear stress and atherosclerosis
Function	Catalytic activity:RX + glutathione = HX + R-S-glutathione.,Function:Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the GST superfamily. Pi family.,similarity:Contains 1 GST C-terminal domain.,similarity:Contains 1 GST N-terminal domain.,subunit:Homodimer.,

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GSTP1 Monoclonal Antibody

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GSTP1 Monoclonal Antibody

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