HAND1 Monoclonal Antibody
Ucallm_WM0230-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | HAND1 |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 24kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 6C6 |
| Immunogen | Purified recombinant fragment of HAND1 (aa90-190) expressed in E. Coli. |
| Specificity | HAND1 Monoclonal Antibody detects endogenous levels of HAND1 protein. |
| Gene Name | HAND1 |
| Protein Name | Heart- and neural crest derivatives-expressed protein 1 |
| Other Name | HAND1; / BHLHA27; / EHAND; / Heart- and neural crest derivatives-expressed protein 1; / Class A basic helix-loop-helix protein 27; / bHLHa27; / Extraembryonic tissues; / heart, autonomic nervous system and neural crest derivatives-expressed protein 1; / eH |
| Species | Human |
| Gene ID | 9421 |
| Uniprot | O96004, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q64279 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus, nucleoplasm . Nucleus, nucleolus . Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). . |
| Tissue Expression | Heart. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells |
| Research Areas | >>Signaling pathways regulating pluripotency of stem cells |
| Function | Function:Plays an essential role in early trophoblast differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box).,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND2 and HEY1, HEY2 and HEYL (hairy-related transcription factors).,tissue specificity:Heart., |
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