Name: HDAC1 [PTR1326] mouse mAb
SKU: WM1356
Price: 268 USD
Availability: InStock

Product details

Background:
histone deacetylase 1(HDAC1) Homo sapiens Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	HDAC1
Reactivity	Human, Mouse, Rat
Applications	WB, IF, ELISA
MW(Calculated)	55kD
MW(Observed)	62kD
Host Species	Mouse
Isotype	IgG1,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Monoclonal
Clone Number	RMMR1326
Immunogen	Synthesized peptide derived from human protein. AA range: 300-482
Specificity	This antibody detects endogenous levels of HDAC1 protein.
Gene Name	HDAC1 RPD3L1
Protein Name	Histone deacetylase 1 (HD1) (EC 3.5.1.98)
Other Name	Histone deacetylase 1; / HD1
Species	Human
Gene ID	3065
Uniprot	Q13547,
Species.1	Mouse
Gene ID.1	433759
Uniprot.1	O09106
Species.2
Gene ID.2
Uniprot.2
Cellular Localization
Tissue Expression	Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
Signaling_pathway	Cellular Processes >> Cell growth and death >> Cell cycle;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway;Organismal Systems >> Aging >> Longevity regulating pathway - multiple species;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Human Diseases >> Cancer: specific types >> Chronic myeloid leukemia;Human Diseases >> Neurodegenerative disease >> Huntington disease;Environmental Information Processing >> Signal transduction >> Notch signaling pathway;Environmental Information Processing >> Signal transduction >> TGF-beta signaling pathway;Genetic Information Processing >> Chromosome >> ATP-dependent chromatin remodeling
Research Areas
Function	Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events . Histone deacetylases act via the formation of large multiprotein complexes . Also functions as deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3 and TSHZ3 . Deacetylates SP proteins, SP1 and SP3, and regulates their function . Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons . Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation . Deacetylates TSHZ3 and regulates its transcriptional repressor activity . Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B . Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity . Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones .