U-Blot® Histone H4 (Acetyl Lys12) Rabbit pAb
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Price range: $288.00 through $368.00
Product details
Background:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015],
Specifications
| Target | Histone H4 |
| Reactivity | Human,Mouse,Rat,Monkey |
| Application | WB,IHC,IF,ELISA |
| MW(Calculated) | |
| MW(Observed) | 11kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Modification | Acetyl |
| Modification site | Lys12 |
| Recommended dilution ratio | WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Histone H4 around the acetylated site of Lys12. AA range:10-59 |
| Sequence | |
| Specificity | This antibody detects histone H2A.Z only when it is L-lactylated at Lys11. detects endogenous levels of Histone H4 protein only when acetylated at K12. |
| Gene name | HIST1H4A/HIST1H4B/HIST1H4C/HIST1H4D/HIST1H4E/HIST1H4F/HIST1H4H/HIST1H4I/HIST1H4J/HIST1H4K/HIST1H4L/HIST2H4A/HIST2H4B/HIST4H4 |
| Protein name | Histone H4 |
| Alternative name | HIST1H4A;H4/A;H4FA;HIST1H4B;H4/I;H4FI;HIST1H4C;H4/G;H4FG;HIST1H4D;H4/B;H4FB;HIST1H4E;H4/J;H4FJ;HIST1H4F;H4/C;H4FC;HIST1H4H;H4/H;H4FH;HIST1H4I;H4/M;H4FM;HIST1H4J;H4/E;H4FE;HIST1H4K;H4/D;H4FD;HIST1H4L;H4/K;H4FK;H4K12AC |
| Organism-1 | Human |
| Gene ID‑1 | 121504;554313;8294;8359;8360;8361;8362;8363;8364;8365;8366;8367;8368;8370 |
| SwissProt-1 | P62805 |
| Organism-2 | Mouse |
| Gene ID‑2 | 100041230 |
| SwissProt-2 | P62806 |
| Organism-3 | Rat |
| Gene ID‑3 | 100360950 |
| SwissProt-3 | P62804 |
| Organism-4 | |
| Gene ID‑4 | |
| SwissProt-4 | |
| Cellular Localization | Nucleus. Chromosome. |
| Unnamed: 38 | |
| Unnamed: 39 |
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