Name: HLA-DOβ Polyclonal Antibody
SKU: WP12699
Price: 268 USD
Availability: InStock

Product details

Background:

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	HLA-DOβ
Reactivity	Human
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	30kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human HLA-DOB. AA range:1-50
Specificity	HLA-DOβ Polyclonal Antibody detects endogenous levels of HLA-DOβ protein.
Gene Name	HLA-DOB
Protein Name	HLA class II histocompatibility antigen DO beta chain
Other Name	HLA-DOB; / HLA class II histocompatibility antigen; / DO beta chain; / MHC class II antigen DOB
Species	Human
Gene ID	3112
Uniprot	P13765
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
Tissue Expression	B-cell,
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> Antigen processing and presentation;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Organismal Systems >> Immune system >> Intestinal immune network for IgA production;Human Diseases >> Immune disease >> Asthma;Human Diseases >> Immune disease >> Systemic lupus erythematosus;Human Diseases >> Immune disease >> Rheumatoid arthritis;Human Diseases >> Immune disease >> Autoimmune thyroid disease;Human Diseases >> Immune disease >> Inflammatory bowel disease;Human Diseases >> Immune disease >> Allograft rejection;Human Diseases >> Immune disease >> Graft-versus-host disease;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas	>>Phagosome; / >>Cell adhesion molecules; / >>Antigen processing and presentation; / >>Hematopoietic cell lineage; / >>Th1 and Th2 cell differentiation; / >>Th17 cell differentiation; / >>Intestinal immune network for IgA production; / >>Type I diabetes mellitus; / >>Leishmaniasis; / >>Toxoplasmosis; / >>Staphylococcus aureus infection; / >>Tuberculosis; / >>Influenza A; / >>Human T-cell leukemia virus 1 infection; / >>Herpes simplex virus 1 infection; / >>Epstein-Barr virus infection; / >>Asthma; / >>Autoimmune thyroid disease; / >>Inflammatory bowel disease; / >>Systemic lupus erythematosus; / >>Rheumatoid arthritis; / >>Allograft rejection; / >>Graft-versus-host disease; / >>Viral myocarditis
Function	Function:Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule.,polymorphism:The following alleles of DOB are known: DOB0101, DOB0102, DOB0103 and DOB0104. The sequence shown is that of DOB*0101.,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Heterodimer of an alpha chain (DOA) and a beta chain (DOB).,

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HLA-DOβ Polyclonal Antibody

Product details

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HLA-DOβ Polyclonal Antibody

Product details

Specifications

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