Name: HLA-DQA1 Polyclonal Antibody
SKU: WP15928
Price: 268 USD
Availability: InStock

HLA-DQA1 Polyclonal Antibody

Ucallm_WP15928-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP15928-100

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Product details

Background:

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marro

Specifications

Size	50μL/100μL
Target	HLA-DQA1
Reactivity	Human
Applications	IHC, IF, ELISA
MW(Calculated)
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the Internal region of human HLA-DQA1. AA range:21-70
Specificity	The antibody detects endogenous HLA-DQA1
Gene Name	HLA-DQA1
Protein Name	HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain) (DC-alpha) (HLA-DCA) (MHC class II DQA1)
Other Name	HLA class II histocompatibility antigen, DQ alpha 1 chain; / DC-1 alpha chain; / DC-alpha; / HLA-DCA; / MHC class II DQA1
Species	Human
Gene ID	100509457
Uniprot	P01909
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
Tissue Expression	Blood,PCR rescued clones,Peripheral blood l
Signaling_pathway
Research Areas	>>Phagosome; / >>Cell adhesion molecules; / >>Antigen processing and presentation; / >>Hematopoietic cell lineage; / >>Th1 and Th2 cell differentiation; / >>Th17 cell differentiation; / >>Intestinal immune network for IgA production; / >>Type I diabetes mellitus; / >>Leishmaniasis; / >>Toxoplasmosis; / >>Staphylococcus aureus infection; / >>Tuberculosis; / >>Influenza A; / >>Human T-cell leukemia virus 1 infection; / >>Herpes simplex virus 1 infection; / >>Epstein-Barr virus infection; / >>Asthma; / >>Autoimmune thyroid disease; / >>Inflammatory bowel disease; / >>Systemic lupus erythematosus; / >>Rheumatoid arthritis; / >>Allograft rejection; / >>Graft-versus-host disease; / >>Viral myocarditis
Function	similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,