Product details
Background:
HMGCL rabbit pAb
Ucallm_WP17895-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | HMGCL |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB |
| MW(Calculated) | 36kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human C-ternal HMGCL |
| Specificity | This antibody detects endogenous levels of HMGCL at Human, Mouse,Rat |
| Gene Name | HMGCL |
| Protein Name | Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (3-hydroxy-3-methylglutarate-CoA lyase) |
| Other Name | Hydroxymethylglutaryl-CoA lyase, mitochondrial; / HL; / HMG-CoA lyase; / 3-hydroxy-3-methylglutarate-CoA lyase |
| Species | Human |
| Gene ID | 3155 |
| Uniprot | P35914, |
| Species.1 | Mouse |
| Gene ID.1 | 15356 |
| Uniprot.1 | P38060, |
| Species.2 | Rat |
| Gene ID.2 | 79238 |
| Uniprot.2 | P97519 |
| Cellular Localization | Mitochondrion matrix . Peroxisome . Unprocessed form is peroxisomal. . |
| Tissue Expression | Highest expression in liver. Expressed in pancreas, kidney, intestine, testis, fibroblasts and lymphoblasts. Very low expression in brain and skeletal muscle. The relative expression of isoform 2 (at mRNA level) is highest in heart (30%), skeletal muscle (22%), and brain (14%). |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Peroxisome |
| Research Areas | |
| Function | Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. |
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