Product details
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HMGCS2 rabbit pAb
Ucallm_WP9023-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | HMGCS2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 56kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human HMGCS2 |
| Specificity | This antibody detects endogenous levels of HMGCS2 at Human, Mouse,Rat |
| Gene Name | HMGCS2 |
| Protein Name | Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase) |
| Other Name | |
| Species | Human |
| Gene ID | 3158 |
| Uniprot | P54868, |
| Species.1 | Mouse |
| Gene ID.1 | 15360 |
| Uniprot.1 | P54869, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P22791 |
| Cellular Localization | Mitochondrion . |
| Tissue Expression | Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas. Very low expression in heart and skeletal muscle (PubMed:7893153, PubMed:21952825, PubMed:16940161). Not detected in brain (PubMed:21952825).; [Isoform 3]: Highest expression detected in heart and skeletal muscle. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> PPAR signaling pathway |
| Research Areas | |
| Function | Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. |
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