Name: HNF1A Polyclonal Antibody
SKU: WP3301
Price: 268 USD
Availability: InStock

HNF1A Polyclonal Antibody

Ucallm_WP3301-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP3301-100

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Product details

Background:

The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],

Specifications

Size	50μL/100μL
Target	HNF1A
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	69kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from part region of human protein
Specificity	HNF1A Polyclonal Antibody detects endogenous levels of protein.
Gene Name	HNF1A TCF1
Protein Name	Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)
Other Name	Hepatocyte nuclear factor 1-alpha; / HNF-1-alpha; / HNF-1A; / Liver-specific transcription factor LF-B1; / LFB1; / Transcription factor 1; / TCF-1
Species	Human
Gene ID	6927
Uniprot	P20823,
Species.1	Mouse
Gene ID.1	21405
Uniprot.1	P22361,
Species.2	Rat
Gene ID.2	24817
Uniprot.2	P15257
Cellular Localization	Nucleus .
Tissue Expression	Liver.
Signaling_pathway
Research Areas	>>Maturity onset diabetes of the young
Function	Disease:Defects in HNF1A are a cause of susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100].,Disease:Defects in HNF1A are the cause of maturity onset diabetes of the young type 3 (MODY3) [MIM:600496]; also symbolized MODY-3. MODY [MIM:606391] is a form of diabetes characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion. The clinical phenotype of MODY3 is characterized by severe insulin secretory defects, and by major hyperglycemia associated with microvascular complications.,Disease:Defects in HNF1A may predispose to hepatic adenomas [MIM:142330]. Hepatic adenomas are benign tumors at risk of malignant transformation. Bi-allelic inactivation of HNF1A, whether sporadic or associated with MODY3, may be an early step in the developmant of some hepatocellular carcinomas.,Function:Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.,online information:Hepatocyte nuclear factors entry,polymorphism:The Ala-98/Val-98 polymorphism is associated with a reduction in glucose-induced serum C-peptide and insulin responses.,similarity:Belongs to the HNF1 homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Binds DNA as a dimer.,tissue specificity:Liver.,