Name: HO-1 Mouse mAb [Mix-mA]
SKU: WM1099
Price: 268 USD
Availability: InStock

HO-1 Mouse mAb [Mix-mA]

Ucallm_WM1099-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WM1099-50

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Product details

Background:
heme oxygenase 1(HMOX1) Homo sapiens Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	HO1
Reactivity	Human, Mouse, Rat
Applications	IHC, WB, IF
MW(Calculated)
MW(Observed)	28kD
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IF 1:50-200; IHC1:50-200; WB 1:1000-2000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Monoclonal
Clone Number	19C10
Immunogen	Synthesized peptide derived from human HO-1
Specificity	This antibody detects endogenous levels of HO-1 at Human, Mouse,Rat
Gene Name	HMOX1 HO HO1
Protein Name	HO-1
Other Name	Heme oxygenase 1; / HO-1
Species	Human
Gene ID	3162
Uniprot	P09601,
Species.1	Mouse
Gene ID.1	15368
Uniprot.1	P14901,
Species.2	Rat
Gene ID.2	24451
Uniprot.2	P06762
Cellular Localization	Endoplasmic reticulum membrane; Single-pass type IV membrane protein; Cytoplasmic side .
Tissue Expression	Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
Signaling_pathway	Cellular Processes >> Cell growth and death >> Ferroptosis;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma;Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Research Areas	>>Porphyrin metabolism; / >>Metabolic pathways; / >>HIF-1 signaling pathway; / >>Ferroptosis; / >>Mineral absorption; / >>Pathways in cancer; / >>MicroRNAs in cancer; / >>Chemical carcinogenesis - reactive oxygen species; / >>Hepatocellular carcinoma; / >>Fluid shear stress and atherosclerosis
Function	Catalytic activity:Heme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O.,Function:Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.,induction:Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA.,similarity:Belongs to the heme oxygenase family.,