Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
| Size | 50μL/100μL |
| Target | HSP 90 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF |
| MW(Calculated) | |
| MW(Observed) | 95kD |
| Host Species | Mouse |
| Isotype | IgG2a,kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000,; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Monoclonal |
| Clone Number | 1F6 |
| Immunogen | Synthesized peptide derived from the C-terminal region of human HSP90A. at AA range: 660-740 |
| Specificity | The antibody detects endogenous HSP90 α protein |
| Gene Name | HSP90AA1 |
| Protein Name | Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Renal carcinoma antigen NY-REN-38) |
| Other Name | Heat shock protein HSP 90-alpha; / Heat shock 86 kDa; / HSP 86; / HSP86; / Renal carcinoma antigen NY-REN-38 |
| Species | Human |
| Gene ID | 3320 |
| Uniprot | P07900, |
| Species.1 | Mouse |
| Gene ID.1 | 15519 |
| Uniprot.1 | P07901, |
| Species.2 | Rat |
| Gene ID.2 | 299331 |
| Uniprot.2 | P82995 |
| Cellular Localization | Nucleus . Cytoplasm . Melanosome . Cell membrane . Mitochondrion . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Tissue Expression | Adult brain,Brain,Brain cortex,Breast,Cajal-Retzius |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Necroptosis;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> Antigen processing and presentation;Organismal Systems >> Immune system >> Th17 cell differentiation;Organismal Systems >> Immune system >> IL-17 signaling pathway;Organismal Systems >> Endocrine system >> Estrogen signaling pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Prostate cancer;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum |
| Research Areas | >>Protein processing in endoplasmic reticulum; / >>PI3K-Akt signaling pathway; / >>Necroptosis; / >>Antigen processing and presentation; / >>NOD-like receptor signaling pathway; / >>IL-17 signaling pathway; / >>Th17 cell differentiation; / >>Progesterone-mediated oocyte maturation; / >>Estrogen signaling pathway; / >>Salmonella infection; / >>Pathways in cancer; / >>Chemical carcinogenesis - receptor activation; / >>Prostate cancer; / >>Lipid and atherosclerosis; / >>Fluid shear stress and atherosclerosis |
| Function | Caution:Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.,Function:Molecular chaperone.,Function:Molecular chaperone. Has ATPase activity.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1 and HSF1., |
