Hsp90 β mouse mAb
Ucallm_WM0700-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012],
Specifications
| Size | 50μL/100μL |
| Target | HSP90β |
| Reactivity | Human, Mouse, Rat, Monkey, Hamster |
| Applications | WB, ICC, IP |
| MW(Calculated) | |
| MW(Observed) | 90kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:2000; ICC 1:200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 12D4 |
| Immunogen | Purified recombinant human Hsp90 beta protein fragments expressed in E.coli |
| Specificity | This antibody detects endogenous levels of Hsp90 beta and does not cross-react with Hsp90 alpha and other proteins. |
| Gene Name | hsp90ab1 |
| Protein Name | |
| Other Name | HSP90AB1; / 90 kda heat shock protein beta HSP90 beta; / D6S182; / FLJ26984; / Heat shock 84 kDa; / Heat shock 90kD protein 1, beta; / Heat shock 90kDa protein 1 beta; / Heat shock protein 90kDa alpha; / cytosolic; / class B member 1; / Heat shock protein beta; / Heat shock protein HSP 90 beta; / Heat shock protein HSP 90-beta; / HS90B_HUMAN; / HSP 84; / HSP 90; / HSP 90 b; / HSP 90b; / HSP84; / HSP90 BETA; / hsp90ab1; / HSP90B; / HSPC2; / HSPCB. |
| Species | Human |
| Gene ID | 3326 |
| Uniprot | P08238, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P11499 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Melanosome . Nucleus . Secreted . Cell membrane . Dynein axonemal particle . Cell surface . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Translocates with BIRC2 from the nucleus to the cytoplasm during differentiation (PubMed:18239673). Secreted when associated with TGFB1 processed form (LAP) (PubMed:20599762). . |
| Tissue Expression | Amygdala,Brain cortex,Colon,Colon carcinoma,Embryon |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Necroptosis;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> Antigen processing and presentation;Organismal Systems >> Immune system >> Th17 cell differentiation;Organismal Systems >> Immune system >> IL-17 signaling pathway;Organismal Systems >> Endocrine system >> Estrogen signaling pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Prostate cancer;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum |
| Research Areas | >>Protein processing in endoplasmic reticulum; / >>PI3K-Akt signaling pathway; / >>Necroptosis; / >>Antigen processing and presentation; / >>NOD-like receptor signaling pathway; / >>IL-17 signaling pathway; / >>Th17 cell differentiation; / >>Progesterone-mediated oocyte maturation; / >>Estrogen signaling pathway; / >>Salmonella infection; / >>Pathways in cancer; / >>Chemical carcinogenesis - receptor activation; / >>Prostate cancer; / >>Lipid and atherosclerosis; / >>Fluid shear stress and atherosclerosis |
| Function | Function:Molecular chaperone. Has ATPase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with TP53/p53 (By similarity). Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer., |
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