Name: IBTK Polyclonal Antibody
SKU: WP0581
Price: 268 USD
Availability: InStock

IBTK Polyclonal Antibody

Ucallm_WP0581-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP0581-100

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Product details

Background:

Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014],

Specifications

Size	50μL/100μL
Target	IBTK
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	148kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human protein . at AA range: 410-490
Specificity	IBTK Polyclonal Antibody detects endogenous levels of protein.
Gene Name	IBTK BTKI KIAA1417
Protein Name	Inhibitor of Bruton tyrosine kinase (IBtk)
Other Name
Species	Human
Gene ID	25998
Uniprot	Q9P2D0,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q6ZPR6
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm. Membrane; Peripheral membrane protein. Translocates to the plasma membrane upon IgM stimulation.; [Isoform 2]: Nucleus.
Tissue Expression	Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues.
Signaling_pathway
Research Areas
Function	Function:Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.,similarity:Contains 2 BTB (POZ) domains.,similarity:Contains 3 ANK repeats.,similarity:Contains 3 RCC1 repeats.,subcellular location:Translocates to the plasma membrane upon IgM stimulation.,subunit:Interacts with the PH domain of BTK.,tissue specificity:Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues.,