IF2M Polyclonal Antibody
Ucallm_WP1867-50
Price range: $268.00 through $328.00
Product details
Background:
During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016],
Specifications
| Size | 50μL/100μL |
| Target | IF2M |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 79kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 450-530 |
| Specificity | IF2M Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | MTIF2 |
| Protein Name | Translation initiation factor IF-2, mitochondrial (IF-2(Mt)) (IF-2Mt) (IF2(mt)) |
| Other Name | |
| Species | Human |
| Gene ID | 4528 |
| Uniprot | P46199, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q91YJ5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Mitochondrion. |
| Tissue Expression | Expressed in all tissues examined. Highest level in skeletal muscle. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.,similarity:Belongs to the IF-2 family.,subunit:Monomer.,tissue specificity:Expressed in all tissues examined. Highest level in skeletal muscle., |
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