Price range: $268.00 through $328.00
Background:The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012],
| Size | 50μL/100μL |
| Target | IFITM3 |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 14kD |
| MW(Observed) | 15kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-200; WB 1:500-2000; IF 1:200-1000; ELISA 1:5000-20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM0253R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | IFITM3 |
| Protein Name | Interferon-induced transmembrane protein 3 |
| Other Name | IFITM3; / Interferon-induced transmembrane protein 3; / Dispanin subfamily A member 2b; / DSPA2b; / Interferon-inducible protein 1-8U |
| Species | Human |
| Gene ID | 2260 |
| Uniprot | Q01628, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9CQW9, |
| Species.2 | Rat |
| Gene ID.2 | 79114 |
| Uniprot.2 | Q04589 |
| Cellular Localization | Membranous |
| Tissue Expression | Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Adherens junction;Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells;Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer;Human Diseases >> Cancer: specific types >> Melanoma;Human Diseases >> Cancer: specific types >> Prostate cancer;Human Diseases >> Cancer: specific types >> Breast cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Ras signaling pathway; / >>Rap1 signaling pathway; / >>Calcium signaling pathway; / >>PI3K-Akt signaling pathway; / >>Adherens junction; / >>Signaling pathways regulating pluripotency of stem cells; / >>Thermogenesis; / >>Regulation of actin cytoskeleton; / >>Parathyroid hormone synthesis, secretion and action; / >>Pathways in cancer; / >>Proteoglycans in cancer; / >>Prostate cancer; / >>Melanoma; / >>Breast cancer; / >>Central carbon metabolism in cancer |
| Function | induction:By alpha and gamma interferons.,similarity:Belongs to the CD225 family., |
