Name: IGFBP3 Polyclonal Antibody
SKU: WP12789
Price: 268 USD
Availability: InStock

IGFBP3 Polyclonal Antibody

Ucallm_WP12789-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP12789-100

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Product details

Background:

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	IGFBP3
Reactivity	Human, Mouse
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	31kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; IHC 1:100-500; IF/ICC1:100-500; ELISA 1:5000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human IGFBP-3. AA range:151-200
Specificity	IGFBP3 Polyclonal Antibody detects endogenous levels of IGFBP3 protein.
Gene Name	IGFBP3
Protein Name	Insulin-like growth factor-binding protein 3
Other Name	IGFBP3; / IBP3; / Insulin-like growth factor-binding protein 3; / IBP-3; / IGF-binding protein 3; / IGFBP-3
Species	Human
Gene ID	3486
Uniprot	P17936,
Species.1	Mouse
Gene ID.1
Uniprot.1	P47878
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Secreted .
Tissue Expression	Expressed by most tissues. Present in plasma.
Signaling_pathway	Cellular Processes >> Cell growth and death >> p53 signaling pathway;Cellular Processes >> Cell growth and death >> Cellular senescence;Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer
Research Areas	>>p53 signaling pathway; / >>Cellular senescence; / >>Growth hormone synthesis, secretion and action; / >>Transcriptional misregulation in cancer
Function	developmental stage:IGFBP3 levels are higher during extrauterine life and peak during puberty.,Domain:The thyroglobulin type-1 domain mediates interaction with HN.,Function:IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.,induction:IGFBP3 levels increase in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone, epidermal growth factor, and phorbol esters.,online information:The Singapore human mutation and polymorphism database,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 thyroglobulin type-1 domain.,subunit:Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN.,tissue specificity:Expressed by most tissues.,