Name: IL-11Rα Polyclonal Antibody
SKU: WP12805
Price: 268 USD
Availability: InStock

IL-11Rα Polyclonal Antibody

Ucallm_WP12805-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP12805-100

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Product details

Background:

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012],

Specifications

Size	50μL/100μL
Target	IL-11Rα
Reactivity	Human
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	45kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from IL-11Rα . at AA range: 300-380
Specificity	IL-11Rα Polyclonal Antibody detects endogenous levels of IL-11Rα protein.
Gene Name	IL11RA
Protein Name	Interleukin-11 receptor subunit alpha
Other Name	IL11RA; / Interleukin-11 receptor subunit alpha; / IL-11 receptor subunit alpha; / IL-11R subunit alpha; / IL-11R-alpha; / IL-11RA
Species	Human
Gene ID	3590
Uniprot	Q14626,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q64385
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	[Interleukin-11 receptor subunit alpha]: Membrane; Single-pass type I membrane protein .; [Soluble interleukin-11 receptor subunit alpha]: Secreted .; [Isoform HCR2]: Secreted .
Tissue Expression	Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2 (PubMed:7670098). Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma.
Signaling_pathway	Organismal Systems >> Immune system >> Hematopoietic cell lineage;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas	>>Cytokine-cytokine receptor interaction; / >>JAK-STAT signaling pathway; / >>Hematopoietic cell lineage
Function	Disease:Increased levels of IL11R are found in prostate carcinoma.,Function:Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells.,similarity:Belongs to the type I cytokine receptor family. Type 3 subfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:On ligand binding, forms a multimer complex with IL6ST/gp130.,tissue specificity:Expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. Also expressed in normal and malignant prostate epithelial cell lines.,