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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/IL-18R Polyclonal Antibody
SKU: WP15500 Categories: ,

IL-18R Polyclonal Antibody

Ucallm_WP15500-50

Price range: $268.00 through $328.00

SKU: WP15500-100
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Product details

Background:

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013],

Specifications

Size50μL/100μL
TargetIL-18R
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)63kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human IL18R1. AA range:231-280
SpecificityIL-18R Polyclonal Antibody detects endogenous levels of IL-18R protein.
Gene NameIL18R1
Protein NameInterleukin-18 receptor 1
Other NameIL18R1; / IL1RRP; / Interleukin-18 receptor 1; / IL-18R-1; / IL-18R1; / CD218 antigen-like family member A; / CDw218a; / IL1 receptor-related protein; / IL-1Rrp; / IL1R-rp; / CD218a
SpeciesHuman
Gene ID8809
UniprotQ13478,
Species.1Mouse
Gene ID.1
Uniprot.1Q61098
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Single-pass type I membrane protein .
Tissue ExpressionHighly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells (PubMed:10925275, PubMed:11046021, PubMed:10653850).
Signaling_pathwayHuman Diseases >> Immune disease >> Inflammatory bowel disease;Environmental Information Processing >> Signal transduction >> TNF signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
Research Areas>>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>TNF signaling pathway; / >>Inflammatory bowel disease
FunctionFunction:Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.,miscellaneous:Does not bind interleukin 1 alpha (IL-1A) or interleukin 1 beta (IL-1B).,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin's disease cell lines.,
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